Work Package 2

GENERATION OF RELEVANT CELLULAR MODELS OF CSDs AND RSDs

Work package leader:

Anna Villa (CNR)

Objectives:

• To establish a range of cellular models of RSDs and CSDs using both physiological and surrogate cell lines.
• To establish primary cell lines from patients and animal models (zebrafish and mouse) carrying different genetic variations.
• To generate iPS cell lines from human cells (e.g. urine & blood cells or skin fibroblasts) of RSD patients.
• To obtain differentiated cells from iPS and mES cells.

Partners involved in WP2:

• University of Newcastle
• University of L’Aquila
• University of Manchester
• University of Pavia
• Consiglio Nazionale delle Ricerche
• Institut National de la Santé et de la Recherche Médicale
• Certus Technology Associates Limited
• Charité – Universitaetsmedizin Berlin
• Evercyte
• University Hospital of Cologne
• University of Freiburg
• University of Antwerp