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- Newcastle University
- University of L'Aquila
- University of Manchester
- Alacris Teranostics GmbH
- University of Pavia
- Polygene
- Consiglio Nazionale delle Ricerche
- INSERM
- Certus Technology
- Charité Universitaet Medizin
- GATC Biotech
- University Medical Center Hamburg Eppendorf
- Evercyte GmbH
- University Hospital of Cologne
- PRIMM Srl
- University of Freiburg
- University of Antwerp
- Finovatis
- Research
- SYBIL at a glance
- Bone
- Growth plate
- Desbuquois dysplasia
- Diastrophic dysplasia
- MCDS
- Osteopetrosis
- Osteoporosis
- Osteogenesis imperfecta
- Prolidase deficiency
- PSACH and MED
- Systems biology
- SOPs
- Alcian Blue staining
- Bone measurements
- BrdU labelling
- Cell counting using ImageJ
- Chondrocyte extraction
- Cre genotyping protocol
- DMMB assay for sulphated proteoglycans
- Densitometry using ImageJ
- Double immunofluorescence
- Electron microscopy of cartilage - sample prep
- Extracting DNA for genotyping
- Grip strength measurement
- Histomorphometry on unon-decalcified bone samples
- Immunocytochemistry
- Immunofluorescence
- Immunohistochemistry
- Quantitative X-ray imaging on bones using Faxitron and ImageJ
- Skeletal preps
- TUNEL assay (Dead End Fluorimetric Kit, Promega)
- Toluidine Blue staining
- Toluidine Blue staining
- Von Kossa Gieson staining
- Wax embedding of cartilage tissue
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Welcome to the SYBIL (Systems biology for the functional validation of genetic determinants of skeletal diseases) project, a five year project funded by the European Commission.
The overall concept of this large-scale collaborative project is to functionally validate genetic determinants of common and rare skeletal diseases to gain a mechanistic understanding of disease processes and age-related changes and to deliver new and validated therapeutic targets. SYBIL brings together a complementary translational and transnational group of world-class scientists, systems biologists, disease modellers, information technologists and industrialists that will achieve critical mass to deliver the ambitious objectives of this programme of research.